Research uncovers new insight into cell development and cancer

Wednesday, January 2, 2013

Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.

The study, published December 27, 2012 by the journal Molecular Cell, implicates a unique class of proteins called polycomb-like proteins, or PCL's, as bridging molecules between the "on" and "off" state of a gene. While all of these specialized types of cells share the same genetic information encoded in our DNA, it is becoming increasingly clear that information outside the genome, referred to as epigenetics, plays a central role in orchestrating the reprogramming of a stem cell down a defined path.

Although it is understood that epigenetics is responsible for turning genes "on" and "off" at defined times during cellular development, the precise mechanisms controlling this delicate process are less well understood.

"This finding has important implications for both stem cell biology and cancer development, as the same regulatory circuits controlled by PCL's in stem cells are often misregulated in tumors," said Dr. Greg Wang, senior author of the study and Assistant Professor of Biochemistry and Biophysics in the UNC School of Medicine and a member of UNC Lineberger Comprehensive Cancer Center.

The study, led by postdoctoral research fellows Drs. Ling Cai and Rui Lu in the Wang lab, and Dr. Scott Rothbart, a Lineberger postdoctoral fellow in the lab of Dr. Brian Strahl, Associate Professor of Biochemistry and Biophysics in the UNC School of Medicine and a member of UNC Lineberger Comprehensive Cancer Center, identified that PCL's interact with an epigenetic signal associated with genes that are turned on to recruit a group of proteins called the PRC2 complex which then turn genes off.

"In stem cells, the PRC2 complex turns genes off that would otherwise promote reprogramming into specialized cells of organs like the heart or lungs," said Wang.

In addition to its fundamental role in cellular development, elevated levels of PRC2 have been found in cancers of the prostate, breast, lung, and blood, and pharmaceutical companies are already developing drugs to target PRC2. Wang and colleagues determined that the same mechanisms controlling PRC2 function in stem cells also applies in human cancers.

"The identification of a specific PCL in controlling PRC2 in cancer cells suggests we may be able to develop drugs targeting this PCL to regulate PRC2 function in a more controlled manner that may maintain PRC2 function in stem cells while inhibiting it in the tumor," said Wang.

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University of North Carolina Health Care: http://www.med.unc.edu

Thanks to University of North Carolina Health Care for this article.

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Source: http://www.labspaces.net/126096/Research_uncovers_new_insight_into_cell_development_and_cancer

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Palestinians will outnumber Israeli Jews by 2020

JERUSALEM (AP) ? The Palestinian statistics bureau estimates that Arabs will outnumber Jews in the Holy Land by the end of the decade, a scenario that could have grave implications for Israel.

The bureau said Tuesday that 5.8 million Arabs live in Israel, the West Bank, Gaza and east Jerusalem. That compares to about 6 million Israeli Jews, according to Israeli data.

It said that based on current birth rates, the two populations would be equal in 2016, and in 2020, Arabs would outnumber Jews by 7.2 million to 6.9 million.

The demographic issue is a main argument for Israeli backers of creation of a Palestinian state. They say relinquishing control of the Palestinian territories and its residents is the only way to ensure Israel's future as a democracy with a Jewish majority.

Source: http://news.yahoo.com/palestinians-outnumber-israeli-jews-2020-173656342.html

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NORTH CAROLINA OPERA TO PERFORM WAGNER CONCERT ...

Photo courtesy of Cory Weaver

North Carolina Opera will open its 2012-2013 season on Jan. 27, 2013 at 3 p.m., with a concert of the music of Richard Wagner , in honor of the bicentennial of the composer?s birth, in Meymandi Concert Hall in Duke Energy Center in Raleigh. The concert will include favorite selections from several of Wagner?s most popular operas, including Act I of Die Walk?re, in what is thought to be the first performance from Wagner?s Ring Cycle in the Triangle, Ride of the Valkyries from Die Walk?re, as well as excerpts from Die Meistersinger, Tristan und Isolde and The Flying Dutchman.

Internationally acclaimed talent will perform, including tenor Jay Hunter Morris, who sings the famously difficult role of Siegfried in Wagner?s Ring Cycle with the Metropolitan Opera; Elizabeth Bishop, who has sung leading Wagner roles at the Metropolitan Opera and San Francisco Opera, as Sieglinde; and Metropolitan Opera bass Peter Volpe as Hunding. NCO Artistic Director and Principal Conductor Timothy Myers will lead 80 members of the North Carolina Opera Orchestra. The two-hour performance will be sung in German with English supertitles.

Richard Wagner (1813-1883) was one of the most important composers of the nineteenth century. Over a twenty-five year period he created the epic four-opera cycle The Ring of the Nibelung, based on Germanic and Norse mythology. The Ring tells the story of the struggle of redemptive love against lust for power, played out over no less a backdrop than the creation and destruction of the world. To tell the story Wagner created a new musical language and even designed a new theater and new instruments. NCO?s performance will include these ?Wagner tubas? in the complete first act of The Valkyrie, the second opera of the cycle.

?North Carolina Opera is excited to perform this amazing collection of Wagner opera in concert, not only because it will be an incredible musical feast of some of opera?s most important and beautiful music on the occasion of the bicentennial of the composer?s birth, but also because it will feature some of opera?s top talents.? said Eric Mitchko, General Director of North Carolina Opera.

With an expansive repertoire of symphonic, ensemble and operatic works, Timothy Myers has proven himself as a conductor of exceptional diversity. His recent engagements include the Beijing National Center for the Performing Arts, Opera Africa, Houston Grand Opera, the North Carolina and Milwaukee symphony orchestras, the Wolf Trap and Central City festivals, and numerous other projects spanning four continents. In 2009 Myers was appointed by Lorin Maazel as the first ever Associate Conductor of the Castleton Festival, where during his two year tenure he was entrusted with multiple symphonic and opera performances. As the Artistic Director and Principal Conductor of North Carolina Opera, Timothy is one of the youngest artistic leaders in American opera. His artistic vision has broadened the company?s repertoire to include a wider variety ranging from Handel to Glass, as well as the creation of innovative and stimulating productions of the classic repertoire. Myers has been engaged for assistant/associate positions with the New York Philharmonic, New York City Opera, London BBC Symphony, as well as principal guest conductor and artistic advisor of the Palm Beach Symphony. He has conducted the Jerusalem Symphony, American Symphony, Brooklyn Philharmonic, the opera companies of Palm Beach, Anchorage and Asheville, the Bard Festival, and Music Academy of the West.

Jay Hunter Morris began the 2012-13 season with his appearance in the principal role of Captain Ahab in Jake Heggie?s celebrated opera, Moby Dick, at San Francisco Opera.? He performed in Florence as Siegmund inDie Walk?re and perform with the Los Angeles Opera as Erik Die Fliegende H?llander. Mr. Morris returns to The Metropolitan Opera for revival performances of The Ring as Siegfried and continues to Glimmerglass Festival for Erik. He makes his debut at Vienna Konzerthaus under the baton of Kent Nagano for performances of Schoenberg?s Gurrelieder. Recent successes include concert performances of Tristan Tristan und Isolde at Palau de les Arts Reina Sofia Valencia and his appearance in the role of Siegfried in the Metropolitan Opera?s new production of the complete Ring Cycle which was broadcast worldwide. Mr Morris embarked on his Ring career when he covered Siegfried Siegfried and G?tterd?mmerung at Seattle Opera in 2009, and the following season at Los Angeles Opera. He also covered the role of Siegmund Die Walk?re during LA Opera?s Ring Cycle in 2010.? In 2011, he made his debut as Siegfried at San Francisco Opera with great success under the baton of Donald Runnicles. One of the hallmarks of Mr. Morris? career is his participation in some of the most noted new work in contemporary opera.? He has created many roles in world premieres, among them the role of Captain James NolanDoctor Atomic at San Francisco Opera, a role he reprised with the Netherlands Opera the following season;? the role of Markyin Cronenburg?s The Fly (Howard Shore) at Th??tre du Ch?telet in Paris, (which he revived at Los Angeles Opera under the baton of Placido Domingo); the role of Unferth in Elliott Goldenthal and Julie Taymor?s Grendel, a performance he repeated in the 2006 Lincoln Center Festival.?

Elizabeth Bishop has been praised by Opera News for her ?gorgeous voice? and is in equal demand for both opera and concert performances across the country. Her 2012-13 season engagements include her first Azucena in Il trovatore with Utah Opera, her first Sieglinde in Die Walk?re with North Carolina Opera, and her return to the Metropolitan Opera for M?re Marie in Dialogues des Carm?lites. Her other Met roles have included Venus in Tannh?user, the title role in Gluck?s Iphig?nie en Tauride, Fenena in Nabucco, and Second Norn in the worldwide Live in HD cinecast of G?tterd?mmerung. Ms. Bishop sings regularly with Washington National Opera, where her roles have included Gertrude in Hamlet, Eboli in Don Carlo, and the Marquise de Merteuil in Conrad Susa?s The Dangerous Liaisons. With Washington Concert Opera she has sung Santuzza in Cavalleria Rusticana and the Princess Bouillon in Adriana Lecouvreur. She has enjoyed a long relationship with San Francisco Opera, appearing there most recently as Fricka in both Das Rheingold and Die Walk?re. She has sung Waltraute in G?tterd?mmerung with the Dallas Opera, M?re Marie with both Deutsche Oper Berlin and Pittsburgh Opera, Eboli with the Teatro Carlo Felice in Genoa, Octavian in Der Rosenkavalier with Donald Runnicles and the Atlanta Symphony, Amneris in Aida with the Atlanta Opera, and Offred in Poul Ruders?s The Handmaid?s Tale with Minnesota Opera. Elizabeth Bishop has appeared as soloist with Amsterdam?s Concertgebouw Orchestra, the Philadelphia Orchestra, the Saint Louis Symphony Orchestra, the Los Angeles Philharmonic, the National Symphony Orchestra, and the Malaysian Philharmonic.

Bass Peter Volpe continually receives critical and popular acclaim on four continents. Possessing a vast and ever-expanding repertoire of over 80 roles in six languages, his captivating style and interpretive skill embraces the depth of historical and fictional characters. Of a recentportrayal as Prince Gremin in Eugene Onegin, Opera News said he ?managed to create in his single aria and scene an impressive dignity. His full-bodied bass and great candor of tone, together with his intelligent interpretation, won him a well-deserved ovation.? In the current season, performances include Ramfis in Aida at Michigan Opera Theatre, Sparafucile in Rigolettoat Manitoba Opera, Ferrando inIl Trovatoreat Arizona Opera, Zuniga in Carmen at the Florentine Opera, the bass soloist in Verdi?s Requiem with the Chattanooga Symphony, and his role debut as Daland in The Flying Dutchman with Glimmerglass Opera.? In addition he will perform Raimondo in Lucia di Lammermoorwith Portland Opera and Philip II in Don Carlo at Austin Lyric Opera.

The Wagner program will include the following, in the order in which they will be presented: Prelude to Die Meistersinger, ?M?gst du, mein Kind? from The Flying Dutchman, ?Fanget an!? from Die Meistersinger, Ride of the Valkyries from Die Walk?re, ?Mild und leise? from Tristan Und Isolde, Intermission and Act I of Die Walk?re.

Ms. Crocetto holds degrees from Siena Heights University in acting performance and Moody Bible Institute in vocal studies. She is a former member of the Sarasota Opera Apprentice Artists Program She was a member of San Francisco Opera?s Merola Opera Program. San Francisco Chronicle said Crocetto has a ?powerful Verdi voice and formidable precision technique, and intensity that amplifies an already huge voice, and an innate, irresistible musicality.? San Francisco Classical voice said, ?In thirty years of exciting discoveries, listening to each group of Merolini for the first time, I have never experienced a singer as complete and awesome as Crocetto.?Tickets are $27 to $85, and are on sale now by calling the North Carolina Opera Box Office at 919-792-3850, filling out the form available at www.ncopera.orgor going to www.ticketmaster.com.

ABOUT NORTH CAROLINA OPERA

North Carolina Opera was formed in 2010 from the merger of Capital Opera Raleigh and The Opera Company of North Carolina. It is dedicated to presenting operatic performances at the highest level throughout the Triangle. We also have a robust education program that brings opera to schools across Wake County and surrounding counties. North Carolina Opera brings international level artists to Raleigh, Durham and Chapel Hill, and also engages the best in local Triangle talent.

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NORTH CAROLINA OPERA TO PERFORM WAGNER CONCERT FEATURING METROPOLITAN OPERA TALENT, 5.0 out of 5 based on 1 rating

Source: http://triangleartsandentertainment.org/event/north-carolina-opera-to-perform-wagner-concert-featuring-metropolitan-opera-talent/

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Bombs kill 23 across Iraq as sectarian strife grows

BAGHDAD (Reuters) - At least 23 people were killed and 87 wounded in attacks across Iraq on Monday, police said, underlining sectarian and ethnic divisions that threaten to further destabilize the country a year after U.S. troops left.

Tensions between Shi'ite, Kurdish and Sunni factions in Iraq's power-sharing government have been on the rise this year. Militants strike almost daily and have staged at least one big attack a month.

The latest violence followed more than a week of protests against Shi'ite Prime Minister Nuri al-Maliki by thousands of people from the minority Sunni community.

No group claimed responsibility for any of Monday's attacks, which targeted government officials, police patrols and members of both the Sunni and Shi'ite communities.

Seven people from the same Sunni family were killed by a bomb planted near their home in the town of Mussayab, south of Baghdad.

In the Shi'ite majority city of Hilla, also in the south, a parked car bomb went off near the convoy of the governor of Babil province, missing him but killing two other people, police said.

"We heard the sound of a big explosion and the windows of our office shattered. We immediately lay on the ground," said 28-year-old Mohammed Ahmed, who works at a hospital near the site of the explosion.

"After a few minutes I stood up and went to the windows to see what happened. I saw flames and people lying on the ground."

In the capital Baghdad, five people were killed by a parked car bomb targeting pilgrims before a Shi'ite religious rite this week, police and hospital sources said.

Although violence is far lower than during the sectarian slaughter of 2006-2007, about 2,000 people have been killed in Iraq this year following the withdrawal last December of U.S. troops, who led an invasion in 2003 to overthrow Sunni dictator Saddam Hussein.

SUNNIS PROTEST

Violence also hit Iraq's disputed territories, over which both the central government and the autonomous Kurdish region claim jurisdiction.

Three militants and one Kurdish guard were killed in the oil-producing, ethnically mixed city of Kirkuk, where militants driving a car packed with explosives tried to break into a Kurdish security office.

Earlier on Monday, two policemen were killed in Kirkuk when a bomb they were trying to detonate exploded prematurely. An army official and his bodyguard were also killed in a drive-by shooting in the south of the city.

Kirkuk lies at the heart of a feud between Baghdad and Kurdistan over land and oil rights, which escalated last month when both sides deployed their respective armies to the swath of territory along their contested internal boundary.

Efforts to ease the standoff stalled when President Jalal Talabani, a Kurd seen as a steadying influence, suffered a stroke and was flown abroad for medical care in December.

Maliki then detained the bodyguards of his Sunni finance minister, which ignited anti-government protests in the western province of Anbar, a Sunni stronghold on the border with Syria.

A lecturer in law at Baghdad University said the protests could help create the conditions for militant Islamist groups like al Qaeda to thrive.

"Raising tension in Anbar and other provinces with mainly Sunni populations is definitely playing into the hands of al Qaeda and other insurgent groups," Ahmed Younis said.

More than 1,000 people protested in the city of Samarra on Monday and rallies continued in Ramadi, center of the protests, and in Mosul, where about 500 people took to the streets.

In the city of Falluja, where protesters have also staged large rallies and blocked a major highway over the past week, gunmen attacked an army checkpoint, killing one soldier.

Protesters are demanding an end to what they see as the marginalization of Sunnis, who dominated the country until the U.S.-led invasion. They want Maliki to abolish anti-terrorism laws they say are used to persecute them.

On Sunday, Deputy Prime Minister Saleh al-Mutlaq, himself a Sunni, was forced to flee a protest in Ramadi when demonstrators pelted him with stones and bottles.

The civil war in neighboring Syria, where majority Sunnis are fighting to topple a ruler backed by Shi'ite Iran, is also whipping up sectarian sentiment in Iraq.

"The toppling of President Bashar al-Assad and empowerment of Sunnis (in Syria) will definitely encourage al Qaeda to regain ground," Younis said.

(Reporting by Ali al-Rubaie in Hilla, Mustafa Mahmoud and Omar Mohammed in Kirkuk, Ali Mohammed in Baquba and Ahmed Rasheed and Aseel Kami in Baghdad; Writing by Isabel Coles; Editing by Alison Williams)

Source: http://news.yahoo.com/explosions-across-iraq-kill-least-10-wound-46-083505805.html

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BlackBerry 10 model RFH121LW hits the FCC, leaves much to the imagination

A day after a BlackBerry 10 device with AT&T LTE support hit the FCC, another mystery model has arrived. The RFH121LW's documents don't reveal much in the way of specs or connectivity -- or even images -- but this is just another reminder that RIM's big BB10 unveiling is around the corner. Those who like to poke through the paperwork can click through to the FCC filing via the link below.

Filed under: Cellphones, RIM

Comments

Source: FCC

Source: http://www.engadget.com/2012/12/31/blackberry-10-rfh121lw-hits-fcc/

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The Correct Way To Use Self-Hypnosis and Psychological Images

Hypnosis permits us to experience thoughts, dreams and pictures as just about real. It also plays a part experiencing discomfort and stress management. Anyway it can change particular behaviors,eg studying, help to manage anger and sadness, build self image, reduce nasty habits, and the like.

The majority can be hypnotised and can use self-hypnosis, says Judie Keys, a Clinical Hypnotherapist in San Diego , California

STEP ONE: Become conversant with self-hypnosis and/or psychological imagery.

Learn all about the fundamentals of hypnosis. Then, practice these systems with a goal in mind; of what you are attempting to achieve with this strategy. It is best to ask a pro help per questions of self-hypnosis.

STEP TWO: Prepare a particular method for prompting self-hypnosis.

You may wish to try hypnotherapy in San Diego. You can learn by heart or record the general induction process into an audiotape and give self- directions. First of all find a quiet, tranquil and comfortable place for the related procedure. Then, imagine your entire body relaxing. Then in time of quietness, a recording of self-instructions can then be played.

STEP THREE: Develop self improvement directions to give yourself during hypnosis.

The self-instructions may reflect a new attitude toward others or yourself, another way of thinking and the like. Words used should be easy but used continually. Except for that, it should be believable, fascinating, used certainly for a specific time and most significantly provide a visible image of the advised result. Write your own instructions for any desired change, e.g. If you're not incentivized at work or at school, write self-suggestions about having the drive and determination to switch, seeing the importance of that change and the superb possible outcomes.

STEP FOUR: Get prepared and have the experience daily.

Find a quiet, private place without any diversions to perform the 20 minutes session. Have your self-instructions ready. Go through the entire routine as you planned it. Develop a hypnosis routine so that you will have the experience simultaneously each day. Be patient, it takes time to learn any new ability.

Source: http://story-nice.blogspot.com/2013/01/the-correct-way-to-use-self-hypnosis.html

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The Real Housewives of Atlanta Recap - Strip No More

Source: http://www.thehollywoodgossip.com/2012/12/the-real-housewives-of-atlanta-recap-strip-no-more/

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